教授、硕士生导师
教育经历：
2005/9-2009/6：武汉大学，生物学基地国际班
2009/8-2016/5：美国康奈尔大学博士
工作经历：
2024/10-至今：湖北工业大学生命科学与健康工程学院，教授
2021/04-2024/03：美国康奈尔大学医学院，助理教授
2020/01-2021/01：美国西奈山医学院呼吸、重症医学和睡眠医学，助理教授
2016/05-2019/12:美国康奈尔医学院，Ansary干细胞研究中心，霍华德休斯干细胞研究所
研究方向
1.血管内皮细胞调控造血干细胞稳态和再生
2.表观遗传因子调控造血干细胞或白血病命运决定
3.血管内皮细胞调控肺损伤和纤维化
主要研究方向为微环境中血管内皮细胞调控造血干细胞的稳态和再生。利用内皮特异性的基因敲除小鼠的模型和体外内皮细胞/造血干细胞共培养（分化）的方法，研究内皮细胞表达的Notch配体Jagged1，Jagged2对造血干细胞的干性维持、定向分化、细胞迁移等作用。建立器官组织特异性的血管内皮细胞系，研究血管内皮细胞调控组织再生的旁分泌功能。博士后研究方向为组蛋白变体H3.3调控造血干细胞干性的分子机制。目前的研究兴趣在于血管内皮细胞分泌的Notch信号配体调控造血干细胞的迁移和定植，血管内皮细胞表达的组蛋白变体H3.3对于造血干细胞干性和分化的调控以及肺纤维化和肺损伤的调控机理。2024年10月加入湖北工业大学生命科学与健康工程学院，担任教授。
以第一作者或通讯作者在同行评审的杂志Nature Cell Biology（IF 17.3），Journal of Clinical Investigation（IF 13.3），Cancer Cell（IF=50.3，Commentary）, Frontiers in Cell and Developmental Biology（IF=4.6）杂志发表系列文章和评论。以共作者的身份在Cell, Nature, Blood, Cell Reports, Clinical and Translational Medicine, Fertility and Sterility, Reproductive Sciences以及Science Immunology上发表12篇文章。文章综合引用数达到2397次。为美国North American Vascular Biology Organization (NAVBO)，New York Stem Cell Foundation (NYSCF)，Gordon Conference in Angiogenesis，Gordon Conference in Notch Signaling, Gordon Conference in Epigenetics的会员。
代表性学术论文和专著
1.Guo P*, Liu Y, Geng FQ, Liu XY, Zhong LW et al, Histone variant H3.3 maintains adult hematopoietic stem cell homeostasis by enforcing chromatin adaptability. (Nature Cell Biology, *,通讯作者，IF=17.3， 中科院一区Top).
在同一杂志Nature Cell Biology上获得同行高度评价：Cipta, N.O., Chen, Y. & Loh, YH. H3.3 safe guards haematopoietic ERV-equilibrium. Nat Cell Biol 24, 7–9 (2022).
https://doi.org/10.1038/s41556-021-00758-y
2. Guo, P., and Rafii, S. (2017). Dangerous Liaisons: Deviant endothelium NOTCHes toward tumor metastasis. Cancer Cell 31, 301–303. (IF=50.3, Commentary，中科院一区Top)
3. Guo, P., Poulos, M.G., Palikuqi, B., Badwe, C.R., Lis, R., Kunar, B., Ding, B.-S., Rabbany, S.Y., Shido, K., Butler, J.M., et al. (2017). Endothelial jagged-2 sustains hematopoietic stem and progenitor reconstitution after myelosuppression. J. Clin. Invest.（IF=13.3，中科院一区）
4. Poulos, M.G., Guo, P., Kofler, N.M., Pinho, S., Gutkin, M.C., Tikhonova, A., Aifantis, I., Frenette, P.S., Kitajewski, J., Rafii, S., et al. (2013). Endothelial Jagged-1 is necessary for homeostatic and regenerative hematopoiesis. Cell Rep 4, 1022–1034. (IF=8.8,中科院一区)
5. Guo, P., Rafii, S.. Generation of BMEC Lines and in vitro BMEC-HSPC co-culture assays. Bioprotocol. 2018 (IF=0.267).
6. Huang, C., Yang, D., Ye, G.W., Powell, C.A., Guo, P.*, Vascular Notch Signaling in Stress Hematopoiesis. Frontiers in Cell and Developmental Biology 8, 1693. (2021, *,通讯作者, IF=4.6，中科院三区)
7. Yang, D., Guo, P., He, T., Powell, C.A. Role of endothelial cells in tumor microenvironment. Clinical and Translational Medicine 11(6) (2021). (IF=10.6，中科院一区)
8. Xie, L., Guo, P., Xiang, M., Song, Y., Wang, X., Powel, C.A., Bai, C., Yang, D.. Tumor endothelial cells for translational research and therapeutics. Clinial and Translational Discovery 2(1), e36 (2022).
9. Cao, Z., Ding, B.-S., Guo, P., Lee, S.B., Butler, J.M., Casey, S.C., Simons, M., Tam, W., Felsher, D.W., Shido, K., et al. (2014). Angiocrine factors deployed by tumor vascular niche induce B-cell lymphoma invasiveness and chemoresistance. Cancer Cell 25, 350–365. (IF=50.3，中科院一区Top)
10. Ding, B.-S., Nolan, D.J., Guo, P., Babazadeh, A.O., Cao, Z., Rosenwaks, Z., Crystal, R.G., Simons, M., Sato, T.N., Worgall, S., et al. (2011). Endothelial-derived angiocrine signals induce and sustain regenerative lung alveolarization. Cell 147, 539–553. (IF=66.85，中科院一区top)
11. Symptoms at disease onset predict prognosis in COVID-19 disease, Chen, P., Zhou, A., Peng, Y., Price, D.R. , Peng, H., Liao, X., Huang, P., Liu, W., Xiang, Z., Liu, Q., Jiang, M., Xiang, X., Guo, P., Deng, D.. Research Square (2020).
12. Brauer, A.A., Kedem, A., Guo, P., Wen, D., Ding, B.-S., Liu, H.-C., Rafii, S., and Rosenwaks, Z. (2013b). Activated ovarian endothelial cells promote early follicular development and survival. Reproductive Sciences 20, 66A–67A. (IF=2.6，中科院三区)
13. Itkin, T. Badwe, C.R., Houghton, S., Lin, Y., Liu, Y., Guo, P., et al, Fli-1 Transcriptionally Integrates Microenvironmental Cues Sensing By Self-Renewing Hematopoietic Stem and Progenitor Cells, Blood, The Journal of the American Society of Hematology 134. (2019) (IF=22.113， 中科院一区Top)
14. Brauer, A.A., Kedem, A., Lis, R., Guo, P., Rafii, S., and Rosenwaks, Z. (2013a). Isolation and chacaterication of ovarian endothelial cells (ECs): a novel tool in understaining the role of endothelial cells in reproductive biology. Fertil. Steril. 100, S60–S61. (IF=6.6，中科院二区)
15. Zhang, X., Zuo, X., Yang, B., Li, Z., Xue, Y., Zhou, Y., Huang, J., Zhao, X., Zhou, J., Yan, Y., Guo, P., et al. (2014). MicroRNA directly enhances mitochondrial translation during muscle differentiation. Cell 158, 607–619. (IF=66.85,中科院一区Top)
16. Wertheimer, T., Velardi, E., Tsai, J., Cooper, K., Xiao, S., Kloss, C.C., Ottmüller, K.J., Mokhtari, Z., Brede, C., deRoos, P., Guo, P et al. (2018). Production of BMP4 by endothelial cells is crucial for endogenous thymic regeneration. Sci. Immunol. 3. (IF=17.6,中科院一区Top)
