职 称：教授、博士生导师
学 历：博士
E-mail：liuxiaonan@hbut.edu.cn
研究方向：1）天然产物合成生物学；2）天然产物后修饰酶的挖掘与智能设计；
基本情况：
刘晓楠，教授，天然产物生物合成与智能设计团队PI。长期从事天然产物合成生物学领域研究。针对具有重要药用价值和应用价值的天然产物，从“生物元件的功能筛选与设计改造”和“细胞工厂的系统构建与过程优化”两方面开展系统研究。基于功能起源进化规律和催化机理，建立生物催化元件精准筛选策略，挖掘并解析多种P450酶、甲基转移酶、糖基转移酶、异戊烯基转移酶的分子基础，首次实现了心脑血管疾病特效药物灯盏乙素、镇咳药物虎杖苷、抗癌药物紫杉醇中间体等20余种天然产物的途径解析和异源合成；构建了目前全球最全面的植物UDP-糖基转移酶和P450酶数据库，开发集数据检索、结构预测、虚拟筛选以及供体预测于一体的网站云平台；建立了非天然P450酶人工智能设计平台和以解脂耶氏酵母为代表的非常规酵母合成生物学平台，实现抗抑郁新药苔黑酚葡萄糖苷、新型甜味剂新橙皮苷二氢查耳酮等创纪录高产；其中发酵法生产新橙皮苷二氢查耳酮项目已经完成技术转让。
2018年获中国科学院大学生物化学与分子生物学博士学位；2015年-2023年中国科学院天津工业生物技术研究所博士后；2023年担任中国科学院天津工业生物技术研究所副研究员；2024年12月-至今担任湖北工业大学生命科学与健康工程学院教授。主持国家自然科学基金面上项目1项、青年基金项目1项、国家博士后科学基金1项，以主要成员参与国家重点研发计划2项、区域创新发展联合基金1项等。以第一或通讯作者（含共同）在Molecular Plant、Nature Communications、Research、Plant Communications、Science China Life Sciences、PloS Biology等期刊发表学术论文18篇。申请发明专利9项，已授权6项。获得2018年度中国科学院院长优秀奖、入选天津市第一批青年科技人才培养项目第三层次、入选中国科学院青年创新促进会会员。
研究课题：
1.国家自然科学基金面上项目:紫杉二烯-5α-羟化酶催化混杂性机制解析与理性设计，主持32371499，项目日期：2024.01-2027.12
2.国家自然科学基金青年基金项目:黄酮8-O-甲基转移酶功能解析与催化机理研究，主持31901026，项目日期：2020.01-2022.12
3.中国博士后科学基金项目:紫杉醇生物合成机制的研究，主持213371，项目日期：2019.11-2021.11
4.国家重点研发计划:甾体激素高效合成人工细胞的创建与优化，参与2019YFA0905303，项目日期：2020.01-2024.12
5.国家重点研发计划:紫杉醇生物合成未知基因鉴定及途径解析，参与2020YFA0908000，项目日期：2020.11-2025.10
科研团队：
团队目前有教师4人，教授1人、副教授2人、讲师1人。其中，博导1人、硕导3人。团队主要从事合成生物学、生物信息学、酶挖掘与智能设计、发酵工程等方面基础应用研究。团队骨干成员均有海内外高水平大学或科研机构学习经历。欢迎有志从事合成生物学领域研究和生物制造产业领域发展的同学报考本团队的博（硕）士研究生，长期招收相关计算生物学、有机化学、合成生物学、发酵工程等相关领域工作人员和博士后。
研究成果：
1.Xiaonan Liu*, Jian Cheng*, Guanghui Zhang*, Wentao Ding, Lijin Duan, Jing Yang, Ling Kui, Xiaozhi Cheng, Jiangxing Ruan, Wei Fan, Junwei Chen, Guangqiang Long, Yan Zhao, Jing Cai, Wen Wang, Yanhe Ma, Yang Dong, Shengchao Yang# and Huifeng Jiang#. Engineering yeast for the production of breviscapine by genomic analysis and synthetic biology approaches.Nature Communications2018, 9 (1): 448.
2. Jian Cheng*, Xiao Wang*,Xiaonan Liu*, Xiaoxi Zhu*, Zihe Li, Huanyu Chu, Qian Wang, Qianqian Lou, Bijun Cai, Yiqun Yang, Xiaoyun Lu, Kai Peng, Dingyu Liu, Yuwan Liu, Lina Lu, Huan Liu, Ting Yang, Qijin Ge, Chengcheng Shi, Guichun Liu, Zhiwei Dong, Xun Xu#, Wen Wang#, Huifeng Jiang# and Yanhe Ma. Chromosome-level genome of Himalayan yew provides insights into the origin and evolution of the paclitaxel biosynthetic pathway.Molecular Plant2021, 14(7): 1199-1209.
3. Yuqian Liu*, Qian Wang*,Xiaonan Liu*, Jian Cheng*#, Lei Zhang, Huanyu Chu, Ruoyu Wang, Haoran Li, Hong Chang, Nida Ahmed, Zhonghua Wang, Xiaoping Liao# and Huifeng Jiang#. pUGTdb: A comprehensive database of plant UDP-dependent glycosyltransferases.Molecular Plant2023, S1674-2052(23)00003-5.
4.Qian Wang*,Xiaonan Liu*, Hejian Zhang*, Huanyu Chu*, Chao Shi*, Lei Zhang, Jie Bai, Pi Liu, Jing Li, Xiaoxi Zhu, Yuwan Liu, Zhangxin Chen, Rong Huang, Hong Chang, Tian Liu, Zhenzhan Chang#, Jian Cheng#, Huifeng Jiang#. Cytochrome P450 Enzyme Design by Constraining Catalytic Pocket in Diffusion Model.Research2024, 8:7:0413.
5. Bihuan Chen*,Xiaonan Liu*, Yina Wang*, Jie Bai*, Xiangyu Liu, Guisheng Xiang, Wei Liu, Xiaoxi Zhu, Jian Cheng, Lina Lu, Guanghui Zhang, Shuhui Zi#, Shengchao Yang# and Huifeng Jiang#. Production of the antidepressant orcinol glucoside in Yarrowia lipolytica with yields over 6,400-fold higher than plant extraction.Plos biology2023, 21(6): e3002131.
6.Xiaonan Liu*#, Xiaoxi Zhu, Jian Cheng, Huifeng Jiang#. A new era for paclitaxel biosynthesis is coming.Molecular Plant2024, 17(3):370-371.
7.Xiaonan Liu*, Jian Cheng*, Xiaoxi Zhu, Guanghui Zhang, Shengchao Yang, Xiaoxian Guo#, Huifeng Jiang# and Yanhe Ma. De Novo Biosynthesis of Multiple Pinocembrin Derivatives in Saccharomyces cerevisiae.ACS Synthetic Biology2020, 9 (11): 3042-3051.
8. Jing Li*,Xiaonan Liu*#, Xiaoxi Zhu, Jiayu Liu, Lei Zhang, Nida Ahmed, Jian Qi, Bihuan Chen, Daliang Tang, Jinsheng Yu, Zhijin Fan#, Huifeng Jiang#.Biochemical synthesis of taxanes from mevalonate.Synthetic and Systems Biotechnology2024, 9 (2024): 694–700.
9. Chunmei Jiang*,Xiaonan Liu*, Xianqing Chen, Yi Cai, Yibin Zhuang, Tao Liu, Xiaoxi Zhu, Hui Wang, Yuwan Liu, Huifeng Jiang and Wen Wang#. Raising the production of phloretin by alleviation of by-product of chalcone synthase in the engineered yeast.Science China Life sciences2020, 63(11): 1734-1743.
10. Xiaoxi Zhu*,Xiaonan Liu*, Tian Liu, Yina Wang, Nida Ahmed, Zhichao Li# and Huifeng Jiang#. Synthetic biology of plant natural products: From pathway elucidation to engineered biosynthesis in plant cells.Plant Communications2021,2(5): 100229.
11.Xiaonan Liu*, Xiaoxi Zhu*, Hui Wang, Tian Liu, Jian Cheng and Huifeng Jiang#. Discovery and modification of cytochrome P450 for plant natural products biosynthesis.Synthetic and systems biotechnology2020, 5 (3): 187-199.
12. Jian Cheng*, Jing Chen*,Xiaonan Liu*, Xiangchen Li, Weixiong Zhang, Zhubo Dai, Lina Lu, Xiang Zhou, Jing Cai#, Xueli Zhang#, Huifeng Jiang# and Yanhe Ma. The origin and evolution of the diosgenin biosynthetic pathway in yam.Plant Communications2020,2(1): 100079.
13. Tian Liu*, Yuqian Liu*, Lan Li*,Xiaonan Liu*#, Zhaokuan Guo, Jian Cheng, Xiaoxi Zhu, Lina Lu, Junlin Zhang, Guanwei Fan, Nengzhong Xie#, Jian Lu# and Huifeng Jiang#. De Novo Biosynthesis of Polydatin in Saccharomyces cerevisiae.Journal of agricultural and food chemistry2021, 69(21): 5917-5925.
14. Yina Wang*,Xiaonan Liu*#, Bihuan Chen, Wei Liu, Zhaokuan Guo, Xiangyu Liu, Xiaoxi Zhu, Jiayu Liu, Jin Zhang, Jing Li, Lei Zhang, Yadi Gao, Guanghui Zhang, Yan Wang, M. Iqbal Choudhary, Shengchao Yang# and Huifeng Jiang#. Metabolic engineering of Yarrowia lipolytica for scutellarin production.Synthetic and Systems Biotechnology2022, 7(3): 958-964.
15. Xiangchen Li*, Jian Cheng*,Xiaonan Liu*, Xiaoxian Guo, Yuqian Liu, Wenjing Fan, Lina Lu, Yanhe Ma, Tao Liu, Shiheng Tao# and Huifeng Jiang#. Origin and Evolution of Fusidane-Type Antibiotics Biosynthetic Pathway through Multiple Horizontal Gene Transfers.Genome Biology and Evolution2020, 12 (10): 1830-1840.
16.Xiaonan Liu*, Wentao Ding* and Huifeng Jiang#. Engineering microbial cell factories for the production of plant natural products: from design principles to industrial-scale production.Microbial Cell Factories2017, 16 (1): 125.
17. Lijin Duan*, Wentao Ding*,Xiaonan Liu, Xiaozhi Cheng, Jing Cai, Erbing Hua#, Huifeng Jiang#. Biosynthesis and engineering of kaempferol in Saccharomyces cerevisiae.Microbial Cell Factories2017, 16 (1):165.
18. Xitong Song*, Qian Wang*, Xiaoxi Zhu*, Wenhan Fang*,Xiaonan Liu, Chao Shi, Zhenzhan Chang#, Huifeng Jiang#, and Binju Wang#.Unraveling the Catalytic Mechanism of Taxadiene-5α-hydroxylase from Crystallography and Computational Analyses.ACS Catalysis2024, 14, 3912−3925.
19.刘晓楠*#，李静，祝晓熙，徐子硕，齐健，江会锋#．紫杉醇生物合成机制研究进展．合成生物学2024，5:1-21.
20.毕慧萍*，刘晓楠*，李清艳，程健，庄以彬，王冬，戴住波，江会锋，刘涛#，张学礼#.植物天然产物微生物重组合成研究进展.生物工程学报2022, 38(11): 4263-4282.
